The potency of selected ethnomedicinal plants from East Kalimantan, Indonesia as antidiabetic agents and free-radical scavengers

Abstract. Ramadhan R, Phuwapraisirisan P, Amirta Darmawan MFB, Ul-Haq K, Kusuma IW, Suwito H, Abdulgani N, Mukhdlor A, Saparwadi. 2022. The potency of selected ethnomedicinal plants from East Kalimantan, Indonesia as antidiabetic agents and free-radical scavengers. Biodiversitas 23: 2225-2231. Ten plant extracts Kalimantan flora, traditionally used to treat blood sugar levels other diabetes-related diseases, were examined in vitro for their free radical scavenging activities by inhibiting rat alpha-glucosidase several radicals such DPPH, ABTS, Nitric oxide respectively. Out the ten species investigated activity against maltase sucrase alpha-glucosidase, three exhibited strongest ?-glucosidaseinhibitory with maltose a substrate, namely Garcinia nervosa, Syzygium caudatilimbum, Shorea balangeran IC50 values 0.046; 0.037; 0.045 mg/mL. Meanwhile, quercetin positive control appeared have comparable IC50value. Furthermore, among extracts, balangeran, Ixora javanica showed good inhibition alpha-glucosidase. Moreover, antioxidant test that methanol an indicated IC50values. present study confirms ethnopharmacological use might potential natural antioxidant.